Reply: The C-CURE Randomized Clinical Trial (Cardiopoietic stem Cell therapy in heart failURE).
نویسندگان
چکیده
A letter to the editor has been submitted to the Journal by Dr. Darrel P. Francis and colleagues regarding the paper by Bartunek et al. (1). Due to the nature, detail, and length of the letter and the corresponding reply, the editors have made a decision to waive the usual word limit and timelines for letters and replies so as to provide a full airing of the issues for our readers. However, given the length of the material, we have elected to place the letter and reply in the online version of the issue.We encourage readers to access this material and trust that it contributes to the editorial process.
منابع مشابه
Paint it black: and seal with a disk.
Klotsche J, TonnT, Dimmeler S, Zeiher AM. Effect of shock wave-facilitated intracoronary cell therapy on LVEF in patients with chronic heart failure: the CELLWAVE randomized clinical trial. JAMA 2013;309:1622–1631. 12. Malliaras K, Makkar RR, Smith RR, Cheng K, Wu E, Bonow RO, Marbán L, Mendizabal A, Cingolani E, Johnston PV, Gerstenblith G, Schuleri KH, Lardo AC, Marbán E. Intracoronary cardio...
متن کاملCongestive Heart Failure Cardiopoietic Regenerative Therapy (CHART‐1) trial design
AIMS Cardiopoiesis is a conditioning programme that aims to upgrade the cardioregenerative aptitude of patient-derived stem cells through lineage specification. Cardiopoietic stem cells tested initially for feasibility and safety exhibited signs of clinical benefit in patients with ischaemic heart failure (HF) warranting definitive evaluation. Accordingly, CHART-1 is designed as a large randomi...
متن کاملCardiopoietic Stem Cell Therapy in Heart Failure
Cardiopoietic Stem Cell Therapy in Heart Failure TheC-CURE (Cardiopoietic stemCell therapy in heart failURE) Multicenter Randomized TrialWith Lineage-Specified Biologics Jozef Bartunek, MD, PHD,* Atta Behfar, MD, PHD,y Dariouch Dolatabadi, MD,z Marc Vanderheyden, MD,* Miodrag Ostojic, MD, PHD,x Jo Dens, MD, PHD,k Badih El Nakadi, MD,z Marko Banovic, MD,x Branko Beleslin, MD, PHD,x Mathias Vroli...
متن کاملCardiopoietic cell therapy for advanced ischaemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial
Aims Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort. Methods and results This multinational, randomized, double-blind, sham-controlled study was co...
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T he therapeutic potential of stem cell treatment for patients with either acute myocardial infarction (AMI) or heart failure (HF) began >15 years ago. Many preclinical studies have been published demonstrating stem cell administration improves myocardial function in animal models of AMI and of HF. Parallel results were found in many small phase 2 clinical trials. However, the results of more r...
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عنوان ژورنال:
- Journal of the American College of Cardiology
دوره 62 25 شماره
صفحات -
تاریخ انتشار 2013